On January 14-16, 2020, one of the partners belonging to the FORTHEM alliance – the University of Burgundy in Dijon, became the organizer of the meeting called the Challenge. It was the second meeting of the international FORTHEM team, attended by representatives of all universities belonging to the alliance. After a successful kick-off meeting (Valencia 2019), it is time to both discuss and agree on the first steps towards achieving the project’s ambitious goals. The key to success is skillful cooperation, taking up challenges and adequate assessment of the situation by all FORTHEM partners.